Project
Project Introduction
Hydrolyzable tannins (gallotannins) are a subclass of polyphenols found in high concentrations in many fruits, nuts, teas, functional foods, and botanicals. While plant-based diets rich in polyphenols are essential for preventing chronic diseases, those with dysbiosis may struggle to metabolize gallotannins effectively, limiting the absorption of beneficial bioactive metabolites. This project aims to explore how probiotic strains can enhance the health benefits of gallotannins, particularly for individuals with obesity-related intestinal microbial dysbiosis.
Gallotannins are metabolized by specific bacteria in the human gut, producing anti-inflammatory metabolites. However, obesity-related dysbiosis can impede this process. Our research team hypothesizes that probiotic strains can restore tannin-hydrolytic activities, thereby increasing the availability of these bioactive metabolites and their anti-inflammatory and anti-obesogenic effects.
In addition to the scientific investigation, this project integrates educational activities designed to support students in STEM. The project aims to foster the development of critical intellectual and transferable skills through individualized mentorship and learning communities, supplementing students’ involvement in laboratory research. Furthermore, the project offers a research-based professional development experience for Texas high school science and career-technology education teachers. As part of this initiative, we will create teaching materials tailored to different grade levels that help both teachers and students learn more effectively. Through this comprehensive approach, we aim to advance scientific understanding while promoting educational and professional development in STEM fields.
Projects
Ex Vivo Anaerobic Fermentations
We are studying how gut bacteria break down fruit extracts differently in lean and obese individuals to understand the health impact of lower tannin-metabolite exposure in obesity.
Clinical Pilot Trial
We are conducting a clinical trial to investigate if gallotannin-rich mango juice with probiotics can improve health markers such as inflammation and metabolism in an obese population.
Integrated Research Experience for Undergraduate Students
Underrepresented undergraduate students participate in integrated research experiences, gaining hands-on involvement in cutting-edge scientific investigations, developing their science identity, and receiving individualized mentorship.
Summer Research Experience for High School Teachers
High-school teachers participate in a 5-day summer workshop featuring research experiences and curriculum development tailored to their classes and aligned with State requirements.
